Derick Lindquist earned his bachelor’s degree in Psychology from Weber State University in 1995. In 1998, he began graduate studies at Yale University. His research focused on the neurobiology of learning and memory—specifically, a form of associative (or Pavlovian) learning known as fear conditioning. Dependent on a brain region called the amygdala, Derick described the amygdala pathways that underlie specific forms of fear conditioning. This work culminated in a doctoral dissertation entitled ‘Cortical-subcortical innervation of the amygdala: Dual input synaptic plasticity and auditory fear conditioning’. Dr. Lindquist received his Ph.D. in Behavioral Neuroscience in 2004.
Following graduation, Dr. Lindquist served as a Postdoctoral Fellow and Research Associate at Indiana University and the University of Kansas, respectively. He studied the cellular and molecular bases of another form of associative learning called eyeblink conditioning. His research investigated the cerebellar pathways and forms of synaptic plasticity that underlie the acquisition and storage of simple sensorimotor memories. He also investigated how the amygdala and cerebellum interact during Pavlovian conditioning, describing how each structure can reciprocally modulate the function of the other.
In 2010, Dr. Lindquist joined The Ohio State University as an Assistant Professor in Psychology. His research focused on the deleterious effects of early-life ethanol exposure in rodents, modeling fetal alcohol spectrum disorders (FASD) in humans. Two important outcomes were demonstrated. First, ethanol exposure in neonate rats disrupts neurodevelopment and induces persistent impairments in cognitive function, especially long-term memory. Second, ethanol-induced inflammation in the developing brain is largely responsible for observed cognitive impairments across maturation. Inasmuch, the administration of anti-inflammatory compounds at the time of ethanol exposure or later in development—i.e., just before a learning and memory behavioral task in adolescent or adult rats—ameliorates deficits in long-term memory. This work has informed our basic understanding of FASD and will contribute to the development of better pharmaco-therapeutics for the treatment of individuals with FASD.
Since 2001, Dr. Lindquist has published over 20 research and review articles in internationally recognized peer-reviewed journals and books. He is also a long-standing member of multiple research societies, including the Society for Neuroscience, the Pavlovian Society, and the Research Society on Alcoholism.